VU 0240551 is primarily used in neuroscience research as a selective antagonist for the KCC2 transporter, which plays a crucial role in regulating chloride ion concentration in neurons. By inhibiting KCC2, it helps researchers study the mechanisms underlying chloride homeostasis and its impact on neuronal excitability. This compound is particularly valuable in investigating conditions like epilepsy, neuropathic pain, and other neurological disorders where disrupted chloride transport is implicated. Additionally, VU 0240551 serves as a tool to explore the potential therapeutic effects of modulating KCC2 activity in various disease models. Its application contributes to a deeper understanding of GABAergic signaling and the development of targeted treatments for neurological diseases.