ML367 is primarily utilized in research settings to study the mechanisms of cellular stress responses, particularly those involving the unfolded protein response (UPR) pathway. It functions as an inhibitor of ATF6, a key transcription factor in the UPR, making it a valuable tool for understanding how cells manage protein misfolding and endoplasmic reticulum (ER) stress. Researchers employ ML367 to investigate its potential in modulating diseases associated with ER stress, such as neurodegenerative disorders, diabetes, and cancer. Additionally, it aids in exploring the role of ATF6 in cellular homeostasis and its implications in therapeutic strategies targeting stress-related pathologies.