Phenoxodiol is primarily investigated for its potential in cancer therapy, particularly in targeting resistant cancer cells. It works by inhibiting key enzymes involved in cancer cell survival, such as topoisomerase II, and promoting apoptosis. Its ability to sensitize cancer cells to chemotherapy and radiation makes it a promising adjunct in treatment regimens. Research also explores its role in overcoming drug resistance in ovarian, prostate, and other cancers, offering hope for improved therapeutic outcomes.