TOPK inhibitor-1 is primarily used in research settings to study the role of TOPK (T-LAK cell-originated protein kinase) in various cellular processes. It is particularly valuable in cancer research, where it helps investigate the inhibition of TOPK, a kinase often overexpressed in cancer cells. By blocking TOPK activity, researchers can explore its impact on tumor growth, proliferation, and metastasis. Additionally, this inhibitor is utilized in studies focusing on DNA damage response and cell cycle regulation, providing insights into potential therapeutic strategies for cancer treatment. Its application extends to understanding the molecular mechanisms underlying drug resistance in certain cancers, aiding in the development of more effective targeted therapies.