Formalin-zinc solution is primarily used in medical and biological fields for tissue preservation and fixation. It is particularly effective in histopathology for preparing tissue samples for microscopic examination. The solution helps maintain cellular structure and prevents decomposition, ensuring accurate analysis.

In dermatology, it is applied to treat conditions like hyperhidrosis (excessive sweating) by reducing sweat gland activity. Additionally, it serves as a disinfectant and antiseptic in certain medical settings due to its antimicrobial properties. Its use in preserving anatomical specimens in educational and research institutions is also notable, as it ensures long-term stability of biological materials.