1-[3,5-Bis(trifluoromethyl)phenyl]-3-[(1R,2R)-2-(dimethylamino)cyclohexyl]thiourea

≥98%,99%e.e.

Reagent Code: #70586
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CAS Number 620960-26-1

science Other reagents with same CAS 620960-26-1

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 413.4 g/mol
Formula C₁₇H₂₁F₆N₃S
thermostat Physical Properties
Melting Point 111-113°C
inventory_2 Storage & Handling
Storage room temperature, dry

description Product Description

This chiral thiourea compound serves as a highly effective organocatalyst in asymmetric synthesis, particularly for enantioselective additions and cycloadditions. Its structure, incorporating a 3,5-bis(trifluoromethyl)phenyl group and a (1R,2R)-2-(dimethylamino)cyclohexyl moiety, enables strong hydrogen-bond donation to activate substrates like imines, promoting stereocontrolled reactions with high enantioselectivity. It is extensively used in the preparation of enantiomerically pure intermediates for pharmaceuticals, agrochemicals, and fine chemicals. While it may have applications in medicinal chemistry research as a modulator of biological targets, its primary role is in synthetic organic chemistry to enhance reaction efficiency and selectivity.

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Test Parameter Specification
Appearance White to off-white solid
Purity 97.5-100
Infrared Spectrum Conforms to Structure
NMR Conforms to Structure

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿1,590.00
inventory 250mg
10-20 days ฿3,600.00
inventory 1g
10-20 days ฿12,000.00

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1-[3,5-Bis(trifluoromethyl)phenyl]-3-[(1R,2R)-2-(dimethylamino)cyclohexyl]thiourea
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This chiral thiourea compound serves as a highly effective organocatalyst in asymmetric synthesis, particularly for enantioselective additions and cycloadditions. Its structure, incorporating a 3,5-bis(trifluoromethyl)phenyl group and a (1R,2R)-2-(dimethylamino)cyclohexyl moiety, enables strong hydrogen-bond donation to activate substrates like imines, promoting stereocontrolled reactions with high enantioselectivity. It is extensively used in the preparation of enantiomerically pure intermediates for ph

This chiral thiourea compound serves as a highly effective organocatalyst in asymmetric synthesis, particularly for enantioselective additions and cycloadditions. Its structure, incorporating a 3,5-bis(trifluoromethyl)phenyl group and a (1R,2R)-2-(dimethylamino)cyclohexyl moiety, enables strong hydrogen-bond donation to activate substrates like imines, promoting stereocontrolled reactions with high enantioselectivity. It is extensively used in the preparation of enantiomerically pure intermediates for pharmaceuticals, agrochemicals, and fine chemicals. While it may have applications in medicinal chemistry research as a modulator of biological targets, its primary role is in synthetic organic chemistry to enhance reaction efficiency and selectivity.

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