N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]thiourea
≥95%,99%e.e.
Reagent
Code: #57487
CAS Number
949480-57-3
science Other reagents with same CAS 949480-57-3
blur_circular Chemical Specifications
scatter_plot
Molecular Information
Weight
420.4 g/mol
Formula
C₁₈H₁₄F₆N₂OS
inventory_2
Storage & Handling
Storage
room temperature, dry
description Product Description
This compound, known as SB-505124, is a potent and selective inhibitor of TGF-β type I receptor kinase (ALK5/TGF-β RI; IC50 = 47 nM). It effectively blocks TGF-β-induced Smad2/3 phosphorylation and is widely used in medicinal chemistry and cell biology research to investigate TGF-β signaling pathways. Its applications include studying fibrosis, epithelial-mesenchymal transition (EMT), cancer progression, inflammation, and immune modulation. SB-505124 serves as a valuable tool for validating drug targets and developing therapeutics for TGF-β-related diseases such as cancer, fibrosis, and autoimmune disorders.
shopping_cart Available Sizes & Pricing
Cart
No products
Subtotal:
0.00
Total
0.00
THB
