Thiosemicarbazide hydrochloride is widely used in organic synthesis as a key reagent for the preparation of thiosemicarbazones, which are important intermediates in the development of pharmaceuticals and agrochemicals. Its ability to form stable complexes with metal ions makes it valuable in analytical chemistry for the detection and quantification of metals. Additionally, it is employed in the synthesis of heterocyclic compounds, which have applications in medicinal chemistry, particularly in the development of antimicrobial, antiviral, and anticancer agents. The compound is also utilized in the production of dyes and pigments, contributing to the textile and coating industries. In research, it serves as a versatile building block for the study of chemical reactions and the development of novel compounds with potential industrial and therapeutic applications.