Bis(2-((tert-butyldimethylsilyl)oxy)ethyl)amine is a protected derivative of N,N-bis(2-hydroxyethyl)amine, featuring two tert-butyldimethylsilyl (TBS) protecting groups on the hydroxyl moieties. It functions as a key building block and intermediate in organic synthesis, particularly for the modification and assembly of nucleosides and oligonucleotides. The TBS groups offer steric protection and chemical stability, enabling selective functionalization at the amine site during the construction of complex biomolecules like RNA and DNA analogs. This compound is essential in solid-phase oligonucleotide synthesis and pharmaceutical applications, facilitating precise molecular architecture. It is widely used to prepare silyl-protected linkers and intermediates for coupling reactions in the production of antisense oligonucleotides, siRNA therapeutics, and related nucleic acid-based drugs.