Used as a derivatization reagent in analytical chemistry, particularly in the detection and quantification of trace thiols and sulfur-containing compounds. Its primary application lies in gas chromatography-mass spectrometry (GC-MS) workflows, where it enhances the volatility and thermal stability of polar analytes. The trimethylsilyl group improves chromatographic behavior by reducing peak tailing and increasing sensitivity. It is especially effective in environmental and biological monitoring, where accurate measurement of reactive sulfur species is critical. The chloro and carbamate functionalities allow for selective reactions under mild conditions, making it suitable for complex sample matrices.