Tris(methylthio)methane is primarily used in organic synthesis as a versatile building block for the preparation of complex molecules. It serves as a key intermediate in the synthesis of various sulfur-containing compounds, which are often utilized in the development of pharmaceuticals and agrochemicals. Its unique structure allows it to act as a precursor in the formation of thioethers and other sulfur-based functional groups, which are critical in drug design and material science. Additionally, it is employed in the production of flavoring agents and fragrances due to its ability to impart sulfurous notes. In research, it is valued for its role in studying reaction mechanisms involving sulfur chemistry.