A 83-01
≥98%
Reagent
Code: #99319
Alias
3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-thiocarboxamide; 3-(6-methyl- 2-pyridyl)-N-phenyl-4-(4-quinolyl)-1H-pyrazole-1-carbothioamide; A83-01; 3-(6-methyl-2-pyridyl) -N-Phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide; A-83-01
CAS Number
909910-43-6
blur_circular Chemical Specifications
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Molecular Information
Weight
421.52 g/mol
Formula
C₂₅H₁₉N₅S
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Storage & Handling
Storage
-20°C, away from light, moisture, airtight and dry
description Product Description
A 83-01 is widely used in biological research as a potent inhibitor of the TGF-β type I receptor kinase, also known as ALK5. It plays a crucial role in studying cellular processes influenced by TGF-β signaling, such as cell differentiation, proliferation, and apoptosis. Researchers utilize it to investigate the mechanisms of fibrosis, cancer progression, and immune regulation. Additionally, A 83-01 is employed in the development of organoid cultures, particularly in maintaining stem cell pluripotency and promoting epithelial cell growth. Its ability to modulate TGF-β pathways makes it a valuable tool in both basic science and therapeutic discovery.
format_list_bulleted Product Specification
| Test Parameter | Specification |
|---|---|
| Appearance | White to orange to green powder to crystalline |
| Purity | 97.5-100 |
| Infrared Spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
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