Tetrazole derivatives are widely used in pharmaceuticals due to their ability to mimic carboxylic acid groups while offering improved metabolic stability and bioavailability. They are key components in drugs such as losartan and other angiotensin II receptor blockers used to treat hypertension. Their polarity and hydrogen-bonding capacity make them valuable in medicinal chemistry for enhancing drug-target interactions. In addition, tetrazoles serve as energetic materials in propellants and explosives because of their high nitrogen content and thermal stability. They are also employed in coordination chemistry as ligands for metal ions, useful in catalysis and material science. In organic synthesis, tetrazoles act as intermediates or building blocks for constructing complex molecules, especially in click chemistry and drug discovery research.