Trans-Tetrahydrofuran-3,4-dicarboxylic acid is primarily used in organic synthesis as a building block for more complex molecules. Its structure makes it valuable in the development of pharmaceuticals, particularly in the creation of compounds with specific biological activities. It is also utilized in the production of fine chemicals and as an intermediate in the synthesis of polymers and resins. Additionally, its unique properties can be exploited in the design of ligands for catalysis, aiding in various chemical reactions. The compound's versatility in forming derivatives makes it a useful tool in research and industrial applications.