Nootkatone is widely used in the fragrance and flavor industry due to its pleasant grapefruit-like aroma. It serves as a natural flavoring agent in foods, beverages, and chewing gums, enhancing citrus notes with a fresh, sweet character. In perfumery, it is valued for adding bright, top-note citrus accords to fine fragrances and personal care products. Beyond flavor and fragrance, nootkatone has gained attention for its insect repellent properties. It is effective against ticks, mosquitoes, and other biting insects, making it a key ingredient in eco-friendly, plant-based insect repellent formulations. Due to its natural origin and low toxicity to mammals, it is used in public health initiatives to help reduce the spread of tick-borne diseases like Lyme disease. Additionally, nootkatone is being explored for its potential in agriculture as a biopesticide and in household products for pest control, offering a safer alternative to synthetic chemicals.