D-α-Hydroxyglutaric acid plays a significant role in various biochemical processes and has applications in both research and medicine. It is involved in metabolic pathways, particularly in the context of certain genetic disorders like D-2-hydroxyglutaric aciduria, where its accumulation can lead to neurological issues. Researchers study this compound to better understand its impact on cellular metabolism and its association with cancer development, as elevated levels have been observed in some tumors. Additionally, it serves as a biomarker for diagnosing metabolic diseases and monitoring disease progression. In the field of biochemistry, it is used as a reagent to investigate enzyme activity and metabolic regulation. Its role in epigenetics is also being explored, particularly in how it influences DNA and histone modifications.