dTAG-13 is utilized primarily in targeted protein degradation studies, particularly in the field of chemical biology and drug discovery. It functions as a heterobifunctional molecule that links a target protein to an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of the protein via the proteasome. This approach is instrumental in probing protein function, validating drug targets, and understanding cellular pathways. dTAG-13 is often employed in research involving conditional protein knockdowns, enabling precise temporal control over protein levels in cells. Its application is especially valuable in studying oncoproteins, transcription factors, and other challenging drug targets, offering insights into disease mechanisms and therapeutic opportunities.