dTRIM24 is a small molecule degrader designed to target the TRIM24 protein, an E3 ubiquitin ligase involved in gene expression regulation and chromatin remodeling. It functions by recruiting TRIM24 to the E3 ligase machinery, promoting its ubiquitination and proteasomal degradation. Primarily used in cancer research, dTRIM24 helps investigate the role of TRIM24 in oncogenesis, particularly in cancers like prostate, breast, and liver cancers where TRIM24 is overexpressed. By depleting TRIM24 levels, it disrupts aberrant transcriptional activity, inhibits cell proliferation, and induces apoptosis in cancer cells. It is also explored for modulating immune responses and serves as a valuable tool in drug discovery for developing targeted protein degraders, such as PROTACs, to address diseases driven by dysregulated transcription factors.