JQ-EZ-05 is primarily utilized in research settings as a potent and selective inhibitor of the enzyme tankyrase, which plays a role in the Wnt/β-catenin signaling pathway. This pathway is crucial in cellular processes such as proliferation, differentiation, and survival, and its dysregulation is often associated with various cancers. By inhibiting tankyrase, JQ-EZ-05 helps researchers study the effects of modulating this pathway, particularly in cancer biology. It is used in laboratory experiments to explore potential therapeutic strategies for cancers driven by Wnt signaling, such as colorectal cancer. Additionally, JQ-EZ-05 serves as a valuable tool in understanding the broader implications of tankyrase inhibition in cellular processes and disease mechanisms. Its application extends to drug discovery efforts aimed at developing targeted therapies for Wnt-dependent diseases.