JWH 081 6-methoxynaphthyl isomer (JWH 166) is primarily utilized in research settings to study its interactions with cannabinoid receptors. It serves as a valuable tool for understanding the pharmacological effects of synthetic cannabinoids on the endocannabinoid system. Researchers use it to explore receptor binding affinities, signaling pathways, and potential behavioral effects. Its application is crucial in advancing knowledge about the structural and functional relationships of cannabinoid receptor agonists, contributing to the development of therapeutic agents or the identification of risks associated with synthetic cannabinoid use. However, it is not intended for human or veterinary use due to its potent and unpredictable effects.