JWH 081 5-methoxynaphthyl isomer is primarily utilized in research settings to study its interactions with cannabinoid receptors, particularly CB1 and CB2. Its structural similarity to naturally occurring cannabinoids makes it a valuable tool for investigating the pharmacological effects and signaling pathways of these receptors. Researchers employ it to explore potential therapeutic applications, such as pain management, appetite regulation, and neuroprotection. Additionally, it is used in the development of new synthetic cannabinoids and to better understand the structure-activity relationships of these compounds. However, its use is strictly confined to controlled laboratory environments due to its psychoactive properties and potential for misuse.