Hexadecylphosphonic acid is widely used as a surface modification agent in materials science, particularly for enhancing the properties of metal oxides and nanoparticles. It is applied to create self-assembled monolayers (SAMs) on surfaces, improving corrosion resistance, adhesion, and hydrophobicity. In the field of nanotechnology, it serves as a stabilizing agent for nanoparticles, ensuring uniform dispersion and preventing aggregation. Additionally, it is utilized in the development of lubricants and coatings, where it provides excellent wear resistance and reduces friction. Its ability to form strong bonds with metal surfaces makes it valuable in the fabrication of advanced materials for electronics, sensors, and biomedical applications.