1-Dodecanethiol is widely used as a surface modifier in the synthesis of nanoparticles, particularly in the production of gold and silver nanoparticles. It acts as a stabilizing agent, preventing aggregation and controlling the size and shape of the nanoparticles, which is crucial for applications in catalysis, electronics, and biomedical fields.

In the field of materials science, it serves as a key component in self-assembled monolayers (SAMs) on metal surfaces, providing hydrophobic properties and improving corrosion resistance. This makes it valuable in coatings and protective layers for various industrial applications.

Additionally, 1-Dodecanethiol is utilized in the production of lubricants and additives, where it enhances the performance of oils and greases by reducing friction and wear. Its ability to act as a chain transfer agent in polymerization processes also makes it important in the synthesis of polymers with specific molecular weights and properties.

In organic synthesis, it is employed as a reagent for introducing the dodecylthio group into molecules, which can modify their chemical and physical properties for targeted applications.