Used as a surface modifier in drug delivery systems, Silica-NH2 enhances particle stability and promotes cellular uptake due to its positive surface charge. It is widely applied in bioconjugation, where the amine groups react with crosslinkers to immobilize proteins, enzymes, or antibodies for biosensors and diagnostic assays. In chromatography, it serves as a functionalized stationary phase for selective separation of biomolecules. Its amine functionality also enables efficient binding of DNA or RNA, making it useful in gene delivery and nucleic acid purification. Additionally, Silica-NH2 is employed in catalysis support, where the amine groups anchor metal catalysts, improving reusability and reaction efficiency.