Used as a key coenzyme in sulfotransferase reactions, facilitating the transfer of sulfate groups to various substrates such as carbohydrates, proteins, and lipids. Essential in the biosynthesis of sulfated compounds like heparin, chondroitin sulfate, and other glycosaminoglycans, which play critical roles in cellular signaling and extracellular matrix structure. Applied in biochemical research to study enzyme kinetics, metabolic pathways, and sulfation processes. Also utilized in drug development to investigate the sulfation of therapeutic compounds, influencing their activity, stability, and excretion.