Ethenesulfonyl fluoride is primarily used in organic synthesis as a versatile reagent for introducing the ethenesulfonyl group into various molecules. It is particularly valuable in click chemistry reactions, where it facilitates the formation of stable covalent bonds with high selectivity and efficiency. This compound is also employed in the development of pharmaceuticals and agrochemicals, where it serves as a key intermediate in the synthesis of active ingredients. Additionally, it finds applications in materials science, contributing to the creation of polymers and coatings with enhanced properties such as durability and chemical resistance. Its reactivity with nucleophiles makes it useful in modifying biomolecules, aiding in the study of protein interactions and enzyme mechanisms.