Pyrimidine-2-sulfonyl fluoride is primarily utilized in organic synthesis and medicinal chemistry as a reactive intermediate. It serves as a key building block in the development of pharmaceuticals, particularly in the synthesis of compounds targeting enzymes and proteins. Its sulfonyl fluoride group is highly reactive, making it valuable for covalent modification of biological molecules, which is useful in drug discovery and proteomics research. Additionally, it is employed in the preparation of agrochemicals and other biologically active molecules due to its ability to introduce functional groups into complex structures. Its applications also extend to material science, where it is used in the design of advanced polymers and coatings.