Sulfonyl chloride, polymer-bound is widely used in organic synthesis, particularly in solid-phase peptide synthesis (SPPS). It serves as a reagent for introducing sulfonyl groups onto molecules, enabling the formation of sulfonamides, sulfonate esters, and other sulfonyl derivatives. Its polymer-bound nature facilitates easy separation and purification of products, making it valuable in combinatorial chemistry and high-throughput screening. Additionally, it is employed in the modification of biomolecules and the development of pharmaceutical intermediates, offering enhanced efficiency and reduced waste in synthetic processes.