7-Iodobenzofuran-5-sulfonyl chloride is primarily used in organic synthesis as a versatile intermediate for the preparation of various complex molecules. Its reactive sulfonyl chloride group makes it valuable for forming sulfonamides, which are commonly found in pharmaceuticals and agrochemicals. The iodine substituent on the benzofuran ring allows for further functionalization through cross-coupling reactions, such as Suzuki or Sonogashira couplings, enabling the creation of diverse chemical structures. This compound is particularly useful in medicinal chemistry for designing drug candidates with potential biological activity. Additionally, it serves as a building block in the development of materials with specific electronic or optical properties, contributing to advancements in material science.