Used primarily as a sulfonylating agent in organic synthesis, enabling the introduction of trifluoroethylsulfonyl groups into molecules. This functionality enhances the stability and lipophilicity of pharmaceutical intermediates, making it valuable in drug development. It is also employed in the preparation of sulfonamide derivatives, which are key structural motifs in various bioactive compounds and agrochemicals. Its strong electron-withdrawing nature facilitates reactions requiring activated sulfonyl intermediates, particularly in the formation of sulfonate esters and sulfonamides under mild conditions. Additionally, it serves in materials science for modifying polymers and creating specialty chemicals with improved thermal and chemical resistance.