Used primarily as a sulfonylating agent in organic synthesis, enabling the introduction of the 2,3,4-trifluorobenzenesulfonyl group to various nucleophiles such as amines and alcohols. This transformation is key in the preparation of sulfonamides and sulfonate esters, which are important motifs in pharmaceuticals and agrochemicals. Its electron-deficient aromatic ring enhances reactivity and influences the stability and biological activity of the resulting compounds. Commonly employed in medicinal chemistry for modifying drug candidates to improve metabolic stability, lipophilicity, and target binding affinity. Also utilized in the development of functional materials where fluorinated building blocks are desired for their unique electronic and physical properties.