Widely used in organic synthesis, particularly as a sulfonylating agent to introduce the 2,6-dimethylbenzenesulfonyl (DMS) group. This group acts as a protecting group for amines and alcohols due to its stability under various reaction conditions and selective deprotection. It is especially valuable in peptide synthesis and medicinal chemistry where controlled functional group manipulation is required. The electron-rich aromatic ring enhances the stability of the sulfonyl derivative, making it suitable for multi-step syntheses. Additionally, it is employed in the preparation of sulfonamides, which are key motifs in pharmaceuticals and agrochemicals. Its steric bulk can influence regioselectivity and reaction outcomes in complex molecule assembly.