Widely used in organic synthesis as a derivatizing agent for amines and other nucleophiles. It introduces the 2,4-dinitrobenzenesulfonyl (DNBS) group, which enhances the detectability and stability of compounds in analytical methods. Commonly applied in the preparation of sulfonamides for pharmaceutical research. Also serves as an intermediate in the development of dyes, agrochemicals, and specialty polymers. Its strong electron-withdrawing nature makes it useful in modifying reactivity in multi-step synthesis.