Widely used as a sulfonylating agent in organic synthesis, particularly in the preparation of sulfonamides, which are key motifs in pharmaceuticals and agrochemicals. Its electron-withdrawing trifluoromethyl groups enhance reactivity and stability, making it effective in forming robust covalent bonds with amines under mild conditions. Commonly employed in medicinal chemistry for the development of bioactive molecules, including protease inhibitors and anti-inflammatory agents. Also utilized in materials science for modifying polymer surfaces to improve chemical resistance and thermal stability. Its high selectivity and reactivity profile make it valuable in multi-step synthesis where functional group tolerance is essential.