Used primarily as a key intermediate in organic synthesis, especially in the development of pharmaceuticals. It reacts with nucleophiles like amines and alcohols to form sulfonamides and sulfonate esters, which are common structural motifs in drug molecules. Its dual sulfone functionality allows for sequential derivatization, making it valuable in building complex molecules. Commonly employed in medicinal chemistry for kinase inhibitor development and in the synthesis of bioactive compounds where sulfonyl groups enhance binding affinity or solubility. Also utilized in peptide chemistry as a protecting group modifier or coupling agent due to its selective reactivity.