3,3-Difluoropyrrolidine-1-sulfonyl chloride
95%
Reagent
Code: #131544
CAS Number
1187160-31-1
blur_circular Chemical Specifications
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Molecular Information
Weight
205.61 g/mol
Formula
C₄H₆ClF₂NO₂S
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Registry Numbers
MDL Number
MFCD27918725
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Physical Properties
Boiling Point
260.7±40.0 °C(Predicted)
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Storage & Handling
Density
1.63±0.1 g/cm3(Predicted)
Storage
2-8°C, Sealed, Inert Gas
description Product Description
Used as a key intermediate in the synthesis of biologically active compounds, particularly in pharmaceuticals and agrochemicals. Its structure enables the introduction of a difluorinated pyrrolidine moiety, which can enhance metabolic stability, membrane permeability, and binding affinity in drug molecules. Commonly employed in the development of protease inhibitors and kinase inhibitors due to its ability to mimic peptide bonds and influence conformational rigidity. Also utilized in the preparation of sulfonamide derivatives through reactions with amines, enabling the expansion of chemical diversity in medicinal chemistry research.
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