Used as a key reagent in organic synthesis, particularly for introducing the pyridine-2-sulfonyl group to amines and alcohols. It is widely applied in the preparation of sulfonamides and sulfonate esters, which serve as intermediates in pharmaceuticals and agrochemicals. Its activating properties make it valuable in peptide synthesis and in the modification of biomolecules. Also employed in the development of functional materials and as a derivatizing agent in analytical chemistry.