Used primarily as a reagent in organic synthesis, this compound is valuable for introducing the 4-nitrobenzenesulfonyl (nosyl) protecting group to amines. It is particularly effective in peptide chemistry, where it helps protect amino groups during synthesis, allowing selective reactions to occur without interference. Additionally, it is employed in the preparation of sulfonamides, which are important in pharmaceutical applications due to their antibacterial properties. Its reactivity with nucleophiles makes it useful in cross-coupling reactions and in the modification of biomolecules.