2-Methylpyridine-4-sulfonyl chloride is primarily used as a key intermediate in organic synthesis, particularly in the preparation of sulfonamide derivatives. These derivatives are widely employed in the development of pharmaceuticals, including antibiotics, anti-inflammatory drugs, and anticancer agents. The compound is also utilized in the synthesis of agrochemicals, where it serves as a building block for creating crop protection agents. Additionally, it finds application in the production of dyes and pigments, contributing to the coloration of various materials. Its reactivity with amines and alcohols makes it a valuable reagent in the modification of polymers and the creation of specialty chemicals.