Sulfonyl chloride polystyrene resin cross-linked with 1% DVB is widely used in organic synthesis as a versatile reagent for functional group transformations. It serves as a solid support for the immobilization of amines, alcohols, and other nucleophiles, enabling efficient synthesis of sulfonamides, sulfonate esters, and related compounds. This resin is particularly valuable in combinatorial chemistry and peptide synthesis, where it facilitates the stepwise assembly of complex molecules with high purity and yield. Additionally, it is employed in the preparation of ion-exchange resins and catalysts, leveraging its robust structure and reactive sulfonyl chloride groups. Its cross-linked nature ensures stability under various reaction conditions, making it a reliable tool in both academic research and industrial applications.