2-Azabicyclo[2.1.1]hexane-2-sulfonyl chloride is primarily used in organic synthesis as a versatile sulfonylating agent for introducing the 2-azabicyclo[2.1.1]hexane-2-sulfonyl group into various nucleophiles, such as amines to form sulfonamides. Its rigid bicyclic structure provides unique stability and reactivity, making it suitable for constructing complex, constrained organic compounds. This chemical is often employed in the preparation of sulfonamides, which are valuable in medicinal chemistry for developing pharmaceuticals with antibacterial, antiviral, or anti-inflammatory properties. Additionally, it serves as a key intermediate in the synthesis of agrochemicals and other fine chemicals, where the sulfonyl group plays a critical role in enhancing biological activity or modifying physical properties. Its application extends to materials science, where it can be used to modify polymers or create specialized coatings.