Widely used in pharmaceutical and agrochemical synthesis as a sulfonylating agent. It introduces the 4-fluoro-3-(trifluoromethyl)benzenesulfonyl group into target molecules, enhancing metabolic stability and lipophilicity. Commonly employed in the preparation of sulfonamides, which are key motifs in drug development. Its electron-withdrawing substituents improve reactivity and influence the biological activity of final compounds. Also utilized in materials science for modifying polymer properties and in research for labeling or derivatization due to the distinct reactivity of the sulfonyl chloride functional group.