Used as a key building block in medicinal chemistry, particularly in the design of bioisosteres. Its rigid, three-dimensional structure helps improve metabolic stability and solubility in drug candidates. Commonly employed to replace phenyl or tert-butyl groups, enhancing pharmacokinetic properties without sacrificing potency. Found in research targeting CNS drugs, where its polarity and shape help cross the blood-brain barrier more effectively. Also utilized in agrochemicals and materials science for introducing strain and unique geometry into molecular frameworks.