Promestriene is primarily used in the treatment of vaginal atrophy, a condition often associated with menopause. It helps to restore the vaginal epithelium and improve symptoms such as dryness, itching, and discomfort during intercourse. Additionally, it is employed in managing certain dermatological conditions, where it aids in enhancing skin hydration and elasticity. Its local application ensures minimal systemic absorption, making it a safer option for patients who cannot tolerate systemic hormone therapy. Promestriene is also utilized in post-surgical or post-radiation therapy to promote the healing of vaginal tissues. Its estrogenic effects are beneficial in maintaining the health and integrity of mucosal surfaces in the genital area.