Oestradiol 17-heptanoate, also known as estradiol enanthate, is primarily used in hormone replacement therapy (HRT) to address symptoms of menopause, such as hot flashes, night sweats, vaginal dryness, and to prevent osteoporosis by maintaining bone density. It is administered as a long-acting estrogen ester, providing sustained release of estradiol into the bloodstream. This makes it effective for maintaining stable hormone levels over an extended period, reducing the need for frequent dosing. Additionally, high doses may be used in the palliative treatment of advanced prostate cancer in men by inhibiting testosterone production. It is also utilized in veterinary medicine to manage reproductive disorders in animals, particularly in livestock, to regulate estrus cycles and improve fertility outcomes. Its lipophilic nature allows for better absorption and prolonged activity, making it a reliable option for both human and animal therapeutic applications.