Used in biochemical and hormonal research to study estrogen metabolism and sulfation pathways. Serves as a stable precursor in the synthesis of active estrogens, useful in assays involving steroid-converting enzymes such as sulfatases and sulfotransferases. Employed in cell culture and in vivo studies to investigate the role of estrogen sulfates in hormone-dependent processes, including reproductive physiology and certain cancers. Also utilized as a reference standard in analytical methods like mass spectrometry and chromatography for detecting estrogen metabolites in biological samples.