Used in biochemical and hormonal research to study estrogen metabolism and sulfation pathways. Serves as a stable precursor in the synthesis of active estrogens, useful in assays involving steroid-converting enzymes such as sulfatases and sulfotransferases. Employed in cell culture and in vitro systems to investigate hormone regulation, receptor activation, and the role of estrogen derivatives in physiological and pathological processes. Also utilized as a reference standard in analytical methods like mass spectrometry and chromatography for detecting estrogenic compounds in biological samples.