tert-Butyl 3,3-difluoro-1,8-diazaspiro[4.5]decane-8-carboxylate
95%
Reagent
Code: #150459
CAS Number
1250999-05-3
blur_circular Chemical Specifications
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Molecular Information
Weight
276.32 g/mol
Formula
C₁₃H₂₂F₂N₂O₂
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Registry Numbers
MDL Number
MFCD17016148
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Physical Properties
Boiling Point
340.7±42.0 °C at 760 mmHg
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Storage & Handling
Storage
-20°C, sealed, light-proof, inert gas
description Product Description
Used as an intermediate in pharmaceutical synthesis, particularly in the development of bioactive molecules targeting central nervous system disorders. Its spirocyclic structure with fluorinated substituents enhances metabolic stability and blood-brain barrier penetration, making it valuable in medicinal chemistry. The tert-butoxycarbonyl (Boc) protecting group allows for selective amine functionalization during multi-step synthesis. Commonly employed in the preparation of kinase inhibitors and GPCR modulators due to its favorable conformational rigidity and polarity profile.
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