JTE-013 is widely used in research to study the role of sphingosine-1-phosphate (S1P) receptors, particularly S1P₂, in various biological processes. It is commonly applied in studies related to inflammation, cancer, and fibrosis, where S1P₂ signaling plays a critical role. Researchers use JTE-013 to inhibit S1P₂ receptor activity, helping to understand its involvement in cell proliferation, migration, and survival. This compound is particularly valuable in investigating the mechanisms of diseases like asthma, atherosclerosis, and certain types of cancer, where S1P₂ signaling is implicated. Additionally, JTE-013 is utilized in preclinical studies to evaluate potential therapeutic strategies targeting S1P₂ receptors.