D-erythro-sphingosine-1-phosphate (C17 base) is widely used in biomedical research due to its role as a bioactive lipid signaling molecule. It is primarily applied in studies related to cell proliferation, migration, and survival, as it interacts with specific G protein-coupled receptors (S1PRs) on the cell membrane. This compound is particularly valuable in understanding immune system regulation, as it influences the trafficking and function of immune cells like T cells and B cells. Additionally, it is utilized in research focused on vascular and neurological systems, where it plays a role in angiogenesis and neuronal protection. Its applications extend to drug development, particularly in targeting inflammatory diseases, autoimmune disorders, and cancer.